INTEGRATED ASSAY WITH SAMPLE PROCESSING: PAPER-BASED DEVICE FOR IgM DETECTION
نویسندگان
چکیده
Point-of Care (POC) devices that can perform multi-step processes, are easy to use, and are inexpensive, are needed for use in limited-resource settings. We present an integrated paper-based device that performs an automated immunoassay for the detection of IgM antibodies with on-board sample processing. The device is a two-dimensional paper network (2DPN) consisting of protein-G coated nitrocellulose for flow-through removal of assay interfering IgG, integrated to a nitrocellulose membrane for lateral flow detection of IgM. The 2DPN is appropriate for POC settings with one user-activation step.
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